AOD9604

What is AOD9604?

AOD9604 (Anti-Obesity Drug 9604) is a synthetic peptide fragment derived from human growth hormone (HGH). Specifically, it corresponds to the C-terminal region (amino acids 176–191) of the HGH molecule — the portion that has been found to regulate fat metabolism without stimulating growth or affecting blood sugar levels.

Originally developed by Metabolic Pharmaceuticals (Australia), AOD9604 was designed as a safe and targeted treatment for obesity and metabolic disorders.

Mechanism of Action

Unlike full-length HGH, AOD9604 does not act as a growth hormone. Instead, it selectively stimulates the breakdown of stored fat (lipolysis) and inhibits the formation of new fat (lipogenesis), particularly in adipose tissue.

Key actions include:

1. Enhancing fat oxidation — promotes the conversion of fat into energy.

2. Reducing fat accumulation — prevents new fat cell formation and triglyceride storage.

3. Improving metabolism — supports overall energy utilization and weight management.

4. Supporting recovery and tissue repair — may help improve muscle healing and joint function.

Importantly, clinical data show that AOD9604 does not raise IGF-1 levels and has no effect on blood glucose or insulin sensitivity, making it safer than traditional HGH therapy.

Clinical Benefits

Studies and early clinical trials have shown that AOD9604 may help:

• Reduce body fat mass, particularly in abdominal and visceral fat areas

• Increase fat metabolism and energy expenditure

• Support weight management when combined with diet and exercise

• Promote muscle recovery and improve joint function, potentially aiding athletes or older adults

Because it lacks anabolic (muscle growth) and diabetogenic effects, AOD9604 is often viewed as a metabolic modulator rather than a hormone.

Administration and Dosage

• Form: Usually administered as a subcutaneous injection, though some formulations exist as oral or transdermal products.

• Typical dosage: 300–500 micrograms per day, depending on the formulation and individual goals.

• Frequency: Once daily, often in the morning or before exercise for optimal fat metabolism.

(Exact dosing should always be guided by a healthcare professional.)

Safety Profile

AOD9604 has been shown in studies to have a favorable safety profile:

• No adverse effects on blood sugar or insulin

• No impact on cell proliferation or organ growth

• Well-tolerated in both short- and long-term use

Reported side effects are rare and mild, including localized redness or discomfort at the injection site.